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Ex clusion criteria included concurrent malignancies; significant medical comorbidities; significant cardiovas cular disease including uncontrolled hypertension, myo cardial infarction, and unstable angina; New York Heart Association grade 2 or greater congestive heart failure; prolongation INNO-406 溶解度 of QTc of more than 450 msec in screening ECG or history of familial long QT syndrome; history of bleeding; proteinuria at baseline, preg nancy or lactation; central nervous system metastases; or an inability to provide written informed consent. Thirty four patients with advanced HCC were enrolled and 23 were included in the current study. The prospective study cohort included 7 men and 16 women, Antiangiogenic treatment The eligibility, treatment schedule, and dose modifica tion schema have been detailed previously, Briefly, eligible patients received sunitinib at a dose of 37.<br><br> Lapatinib 分子量 5 mg daily by mouth for 28 days followed by 14 days of rest in 6 week cycles. Patients with grade 3 or 4 toxicities under went dose reduction to 25 or 12. 5 mg daily, respectively. Treatment was continued until progression, unacceptable toxicity, or withdrawal of consent. Response and progres sion were evaluated using the RECIST after completion two cycles of sunitinib therapy. Imaging protocol This clinical trial was designed not only to investigate the role of DWI and MRP for monitoring early antiangiogenic treatment effects but also to study the overall survival and PFS. The DWI, MRP and delayed postcontrast T1 weighted images were performed at base line and two weeks after initiation of antiangiogenic treatment.<br><br> A re staging contrast enhanced MRI was performed at the end of cycle 2 treatment with LY2109761 700874-71-1 sunitinib for response status and then at every 6 weeks until disease progression. The data acquisition parameters, the same injection proto col and the anatomic location for scanning, including the total duration, were kept constant for each patient and for each repeat DWI, MRP and CE MRI study. DWI DWI of the liver was performed using a phased array body coil on a 1. 5 T MRI system using the following protocol. T1 weighted in phase and out of phase images echo time, 122 159 2. 38 4. 72 msec; one signal acquired; flip angle, 70 degree; 20 slices; section thickness, 5 7 mm; 1 mm interslice gap and axial respiratory triggered fast spin echo T2 weighted images were acquired first.<br><br> Thereafter, an axial respiratory gated echo planar diffusion weighted sequence with spec tral fat saturation was performed by using the follow ing parameters: b values of 50, 400 and 800 sec mm2; TR TE, 4959 7936 44 74 msec; two signals acquired; echo train length, 1; flip angle, 60 90 degree; 20 slices; section thickness, 5 8 mm; 1 mm interslice gap; field of view, 263 × 350; matrix, 144 × 192. The total acquisition time is 3 6 min. MRP MRP of the liver was performed using a phased array body coil on the same 1. 5 T MRI system using the following protocol. At first, three dimensional volume interpolated excitation coronal T1 sequence was obtained in a breath hold before contrast media injection using the following parameters: TR 5 msec, TE 1. 58 msec, 5 mm slice thickness, 1 mm interslice gap, 20 slices, 123 × 192 matrix, and field of view of 400 × 400 mm. Thereafter, through the 20 guage periph eral intravenous line in the arm, 0.